Limited Sampling Strategies to Estimate the Area under the Concentration-time Curve
نویسندگان
چکیده
H. Tsuruta1; M. Fukumoto2; L. Bax3; A. Kohno4; Y. Morishita4 1Department of Medical Informatics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan; 2Division of Toxicology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan; 3Pharsight Corporation, Sunnyvale, CA, USA; 4Department of Hematology and Oncology, Japan Agricultural Cooperatives, Aichi Konan Kosei Hospital, Aichi, Japan
منابع مشابه
Limited sampling strategies to estimate the area under the concentration-time curve. Biases and a proposed more accurate method.
BACKGROUND Over 100 limited sampling strategies (LSSs) have been proposed to reduce the number of blood samples necessary to estimate the area under the concentration-time curve (AUC). The conditions under which these strategies succeed or fail remain to be clarified. OBJECTIVES We investigated the accuracy of existing LSSs both theoretically and numerically by Monte Carlo simulation. We also...
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